Chromosome breakage and sister chromatid exchange analysis in computer operators
نویسندگان
چکیده
منابع مشابه
Sister chromatid exchange analysis in some Holstein bulls
Chromosomal appearance of 12 Holstein bulls selected for artificial inseminations were examined bysister chromatid exchanges (SCEs). For differential staining of sister chromatids bromodeoxyuridine (BrdU)was inoculated in lymphocyte cultures. The mean, maximum and minimum number of SCE per cell weredetermined 6.8 ± 1.14, 8.3 ± 1.1 and 5.7 ± 1.5, respectively. SCE frequencies of all animals were...
متن کاملSister chromatid exchange in Philadelphia chromosome (Ph1)-positive leukemia.
The sister chromatid exchange (SCE) frequency was studied in the leukemic cells of 12 patients, 10 with Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML), 1 with Ph1-negative CML, and 1 with acute myeloblastic leukemia. Except for two patients in the blastic phase of CML, the SCE values were within the normal range [3.8 +/- 6.4 (S.D.) SCE/cell; normal is 3.3 +/- 2.2 SCE/c...
متن کاملSister chromatid exchange in cancer.
Sister chromatid exchange (SCE) techniques have been shown to have great potential for use in the in vitro screening of suspected mutagens and carcinogens. Application of these techniques to bone marrow cells and/or lymphocytes from patients with various hematologic malignancies has demonstrated significant abnormalities in SCE frequencies in some of these diseases, as well as showing drug trea...
متن کاملElevated Rates of Sister Chromatid Exchange at Chromosome Ends
Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, res...
متن کاملsister chromatid exchange analysis in some holstein bulls
chromosomal appearance of 12 holstein bulls selected for artificial inseminations were examined bysister chromatid exchanges (sces). for differential staining of sister chromatids bromodeoxyuridine (brdu)was inoculated in lymphocyte cultures. the mean, maximum and minimum number of sce per cell weredetermined 6.8 ± 1.14, 8.3 ± 1.1 and 5.7 ± 1.5, respectively. sce frequencies of all animals were...
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ژورنال
عنوان ژورنال: Journal of Environmental Science and Health . Part A: Environmental Science and Engineering
سال: 1987
ISSN: 0360-1226
DOI: 10.1080/10934528709375383